When pregnancy was achieved, the combination of E 2 valerate and progesterone supplementation . Within the 3rd decile (HCG range 2945 IU/l), the probabilities of biochemical pregnancy, miscarriage, and normal pregnancy were similar, about 31% each. I have transferred two frozen embryos on May 22nd and my first beta on May 31st was 28. The median hCG level in twin pregnancies was almost double that in singleton pregnancies (201 mIU/mL vs. 115 mIU/mL). Guth B, Hudelson J, Higbie J, Solomon B, Polley S, Thomas S, Gentry WL. For the speediest answer, check out our FAQ section. This culture usually takes place 2-5 days before the embryo is transferred to the wife's uterus. ROC curve of -hCG level at 14 days after oocyte retrieval for predicting . Male factor infertility and ICSI are associated with relatively low HCG values in viable pregnancies. Although I strive to provide accurate general information, the information presented here isnot intended for the prevention or treatment of infertility and it isnot a substitute formedical or professional advice. 2020 Oct 20;15(10):e0240882. In general, the HCG level will double every 2-3 days in early pregnancy. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). 2/8 would be 1dp, correct. Finally, you enter the results from the second test. Enter the date of your first hCG test. Hum Reprod 2002; 17:1901-05). The frozen embryo is thawed before the transfer . It is called the pregnancy hormone because it is only present during pregnancy and can be detected by early pregnancy tests or a blood test. Human chorionic gonadotropin (hCG) is a hormone that is released by the human embryo after conception. 3 While you should report any unusual bleeding to your doctor, spotting alone is not necessarily a good or bad sign. The treatment protocols in fresh and frozen embryo transfers differ, which may have an impact on endometrial maturation and on the HCG levels. You have done everything you can up to this point. You should not rely solely on this information. BACKGROUND: Assisted reproduction treatment (ART) entails a risk of ectopic pregnancy and early pregnancy loss. 3 4 Second trimester pregnancy: 25.6 to 89.4 ng/mL. During IVF, however, final egg maturation is triggered by an hCG injection (generally 10,000 units) given approximately 36 hours prior to egg retrieval, increasing hCG levels in the patient's body. Serum hCG values for viable and non-viable pregnancies were compared by Student's t test. As soon as fertilization begins, the embryos begin aging. Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. Serum HCG concentrations were measured by fluoroimmunometric assay. Sign up for insider access, exclusive deals, and OBGYN insights! BFP April 12 - E born December 2012 at 39w, 1d Report 0 Reply. The approximately doubled HCG level in twin pregnancies is in accordance with the results of previous studies (Schimdt et al., 1994; Glatstein et al., 1995; Bjercke et al., 1999). Please whitelist our site to get all the best deals and offers from our partners. Conclusions: My clinic has me on HCG boosters so I know this will show a slight positive so they asked me to repeat my levels in 2 days to be sure. The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. Background: Unfortunately yes. You will then receive an email that contains a secure link for resetting your password, If the address matches a valid account an email will be sent to __email__ with instructions for resetting your password, DOI: https://doi.org/10.1016/S0015-0282(03)01359-1, Reproductive Science Ctr, Boston, MA, USA. However, if your hCG level is falling, it is likely that the implantation was not successful. Male factor infertility was associated with viable pregnancy, probably reflecting normal female fertility combined with suboptimal male fertility. All my other transfers were 6 day embabies. Beta human chorionic gonadotropin (b-hCG), the hormone that indicates that the fertilized egg has implanted into the uterine wall, rises at around 7 8 days after implantation. Would you like email updates of new search results? Day of transfer is 0dp. Gold RS, Azem F, Yovel I, Wagman I, Amit A, Lessing JB. You have no idea how much you just put me at ease. His embryo transfer date is March 1, 2017 and input 01/03/2017. They still seem very low to me if I compare my numbers to others, but we probably shouldnt be doing that. There are many options available, so talk to your fertility specialist about how best to proceed after a failed embryo transfer. According to available research, it occurs in 7 to 42 percent of IVF cycles. For full access to this pdf, sign in to an existing account, or purchase an annual subscription. 1 7 7 comments Best Add a Comment [deleted] 2 yr. ago The EP represented 59% at HCG ranges up to 80 IU/l, and only one subject with EP had a level higher than this (144 IU/l). I heard hcg doubles every 48 hours, does this apply to whatever baseline we have? The hCG level has to rise appropriately (it doubles every 3 days or so in early pregnancy) till it reaches around 1500 mIU/mL. During 19941999, a total of 1888 embryo transfers were carried out at the Infertility Clinic of Helsinki University Central Hospital, Helsinki, Finland. J Assist Reprod Genet. since the most important part is for HCG to double in 48-72 hours .Hopefully it does . The hCG injection, or the trigger shot, is used to mature the eggs retrieved during your egg retrieval. This hCG calculator can do for you. Just praying that things double on Thursday as they should. Normally, you do your first pregnancy test (HCG blood test) 14 days after embryo transfer. eCollection 2020 Jun. It's a little low, so I hope that the level today is what you are looking for. During 1994-1999, we studied 774 embryo transfer cycles resulting in pregnancy defined as a serum HCG concentration of > or =5 IU/l on day 12 following embryo transfer. The number of women was 650. A high beta hCG could indicate multiples (twins or triplets), which would be confirmed through an ultrasound. There are no suggestions because the search field is empty. Don't obsess. Yesterday at 15dp5dt I went for a blood test and my HCG is only 150. Several studies have confirmed that serum -hCG is a reliable index for predicting early pregnancies at 12-18 days post-transplantation (dpt). The higher the percentage of rise in hCG drawn two days following the initial beta, the better the chances for success. Most HPTs will pick up an HCG reading 11 or 12 days after the embryo enters the uterus. I tested positive on 5DPT. What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. Some recent studies have shown that the rise could be as slow as 53% in two days and the pregnancy could still turn out to be normal. Then, you move onto a vaginal ultrasound at five to eight weeks to look for both a heartbeat and a gestational sac to confirm the pregnancy. this gives me so much hope! That's what I thought. IQ range = interquartile range (i.e. The ROC curve was constructed by plotting the true positive rate (sensitivity) on the y-axis and the false positive rate (1-specificity) on the x-axis for a given HCG concentration. Your example has renewed my faith that maybe this can work out! We are cautiously optimistic if there is a level under 50 on the first test. ACOG Practice Bulletin No. It takes longer to start the implantation process and achieve a high enough hCG level to get a positive pregnancy test. These numbers are specific to the assay the researchers used (solid phase, two-site fluroimmunometric assay calibrated against the WHO Third International Standard of hCG for immunoassay). In simplest terms, the beta hCG test tells you how much hCG is in the blood. :) Best wishes to you! Patients who had serum hCG concentrations higher than 5IU/l on D12 post embryo transfer were stratified and evaluated. think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. We found similar HCG levels in fresh and frozen embryo transfer cycles as well as within the frozen embryo transfer group divided into natural and substituted cycles. Is this too low?? Epub 2022 Jun 25. The detection limit of many at-home pregnancy tests is approximately 25mlU/ml. Yanaihara A, Ohgi S, Motomura K, Hagiwara Y, Mogami T, Saito K, Yanaihara T. BMC Pregnancy Childbirth. With that in mind, here are examples of a normal doubling rate and a lower than normal doubling rate. Notice this step is to examine, not judge. I had my transfer November 22nd with one frozen embryo. But what's more important than the absolute beta number that helps determine normal levels is the rate of increase over time (it should double every 48 hours). When serum -hCG levels 12 days after transfer were evaluated according to the transfer day, the values that were most reliable in predicting clinical pregnancy were 57 mIU/mL for day 3 transfer cycles (sensitivity 71.2%, specificity 64.7%, CI: 0.59-0.79) (Figure 3), and 87 mIU/mL for day 5 transfers (sensitivity 71.2% Bookshelf Initiation of oral contraceptive pills Baseline ultrasound Ovarian stimulation and monitoring Final maturation HCG (trigger shot) and oocyte retrieval Fertilization Embryo transfer (3, 5, or 6 days after retrieval) Pregnancy test (10-12 days after transfer) Early OB ultrasound (6 1/2 weeks gestation) Initiation of oral contraceptive pills There are many variables that can affect hCG values, including the assay that is being used. Here is some information that can help you use them. Data on the outcomes were retrospectively retrieved from the records. Clipboard, Search History, and several other advanced features are temporarily unavailable. Lower levels can indicate a failed pregnancy or an ectopic pregnancy. The level of hCG should rise until you are 11 weeks pregnant. The mean -hCG concentrations on days 11, 14 and 21 after OR in fresh IVF/ICSI cycles and on days 6, 9 and 16, respectively, after blastocyst transfer in cryocycles, were significantly lower in the group of patients with a miscarriage compared to the group with a term delivery (p = 0.02, < 0.001 and < 0.001, respectively). A study of 177 IVF cycles showed that pregnancies with a beta hCG concentration<85 mIU/mL at Day 13 had an 89% risk of having a first trimester miscarriage, and pregnancies with -hCG >386mU/mL had a 91% chance of a live birth. A previous study (Gold et al., 2000), reported lower HCG concentrations 16 days after embryo transfer in ICSI compared with IVF in the subgroup of unexplained infertility. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. 2. The intra-assay variation was 2.75.1% and inter-assay variation 1.63.9% at the studied HCG levels. I now keep saying slow and steady wins the race! Male factor infertility was associated with viable pregnancies (P = 0.004) and tubal factor with non-viable pregnancies (P = 0.003); the lowest HCG level (88 IU/l) was observed in subjects with both male factor infertility and ICSI treatment (P = 0.001). Make An Appointment With Dr. Robles To Discuss Your Fertility Options Today! A high beta hCG could indicate multiples (twins or triplets), which would be confirmed through an ultrasound. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. My home pregnancy tests have been stronger every day but the digital one only said 1-2 weeks. . I took tests all Hi folks,I have read the forum a lot over the last two years but written only once. Is it normal for after 2 weeks? J Reprod Med. (, Strandell, A., Thorburn, J. and Hamberger, L. (, Sugantha, S., Webster, S., Sundar, E. and Lenton, E. (, Tiitinen, A., Halttunen, M., Hrkki, P., Vuoristo, P. and Hyden-Granskog, C. (, Tulchinsky, D., Tulchinsky, A., Paoletti-Falcone, V., Nash, H., Pazdziorko, S. and Brown, K. (, Oxford University Press is a department of the University of Oxford. The differences could be partly due to the different HCG assays used, and partly due to our decision, unlike the others, to regard the five late miscarriages (which have relatively high initial HCG) as non-viable pregnancies. Before you can calculate any results, you need to enter the results from a second test that was done. Urine tests. Affiliates + [email protected]. so true! If you find an IVF hCG calculator online, you may notice the word beta, as in the beta hCG level. Most people do not understand what this means. I had my transfer November 22nd with one frozen embryo. A single cut-off level is always a matter of choice. When two or more follicles reached a diameter of >17 mm (in TVS), 10 000 IU of HCG was administered. The first step in determining the success of an embryo transfer after an IVF cycle is waiting for a positive pregnancy test. Neither odds of implantation nor clinical pregnancy were influenced by maternal age, BMI or blastocyst expansion grade. It is not a pregnancy test. Some calculators are easier to understand than others are. 2022 Sep;39(9):2051-2059. doi: 10.1007/s10815-022-02553-6. (, Glatstein, I., Hornstein, M., Kahana, M., Jackson, K. and Friedman, A. RESULTS: The median HCG concentration was 126 IU/l in viable pregnancies and 31 IU/l in non-viable pregnancies (P < 0.0001). Congratulations! Copyright 2023 European Society of Human Reproduction and Embryology. What Does a Round or Cycle of IVF Even Mean? Clinics recommend a two-week wait after your embryo transfer because taking a pregnancy test too soon after the frozen egg transfer often produces false results. When I got pregnant with my daughter back in February 2014 I tested 9dp5dt and my first beta was 36. Read More. 2000 Jun;15(6):1221-4. doi: 10.1093/humrep/15.6.1221. That is still normal range. Get your query answered 24*7 only on | Practo Consult . That's a great number for only 8dpt but what will really matter is if it doubles! A doctor can also check for pregnancy by ordering a blood test to measure hCG levels. One study broke out twin pregnancies and found that a beta HCG on day 13 after an embryo transfer of <207 mIU/mL had a 33% chance of delivering twins and a 55% risk of having a vanishing twin. We provide probabilities for each type of outcome for a given HCG level to help clinicians to counsel the patient and to plan the next step in her follow-up. Some fertility clinics check that the medication worked by checking your hCG hormones the next day after the trigger shot. Results. The test was considered positive if the -hCG level was > 5 IU/l. hCG levels below 5 mIU/mL are considered negative for Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. This educational content is not medical or diagnostic advice. Curious what individuals HCG levels were for a 5 day embryo transfer? Last chance to preorder our new Hydration & Energy Electrolyte Drink Mix for 10% off at checkout with code HYDRATE. It is usually scheduled 1 month after the embryo transfer or 15 days after a positive hCG result. First, its because 5 mUI/ml hCG level is not indicative of pregnancy after IVF; it only indicates that there is hCG present in the body. In a non-pregnant woman, they are less than 10 mIU/ml. This product is not intended to diagnose, treat, cure, or prevent any disease.Free Standard Shipping is valid on all US orders of $35 or more; free standard shipping is also valid on all recurring subscription orders and multi-packs, bundles, and duos. The presence of both factors together resulted in the lowest HCG concentrations among viable pregnancies. But a blood test can detect it earlier. There are cases of multiple pregnancy that reach values close to 600 mIU/ml within 14 days after embryo . Some women normally have a certain amount of hCG in the body naturally. Supplements to Take During Fertility Treatments and IVF, The IVF Funnel: Understanding Your Chances of Success, 10% off your first month when you subscribe with code LUCKY23, Ovulation support program with a licensed healthcare provider. thank you! In contrast, tubal factor infertility was associated with non-viable pregnancies, at least partly due to the increased incidence of EP (6% with tubal factor infertility compared with 0.8% without). Dr. Karande is Board Certified in the specialty of Obstetrics and Gynecology as well as the subspecialty of Reproductive Endocrinology and Infertility. I know it differs so much by pregnancy. After 36-40 hours of ovulation induction, the wife will be anesthetized to collect the eggs while the husband will have the sperm collected. The objective of our study was to use day 12 post-embryo transfer HCG concentrations to predict outcome of pregnancies following ART, taking into account the aetiology and treatment of infertility. The pregnancy test is the earliest indicator of whether or not your IVF (or, more specifically, embryo transfer) worked. A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. Data on the outcomes were retrospectively retrieved from the records. Markers have been sought to distinguish between viable and non-viable pregnancies before verification of live intrauterine pregnancy by transvaginal sonography (TVS) is possible. Serum hCG values for viable and non-viable pregnancies were compared by Students t test. I had 1 AA/5 day embryo transferred 12 days ago and got a positive blood test but with a hCG level of 12.2. I think they are trained to say that kind of thing. Epub 2010 Jan 11. The median HCG concentration was 126 IU/l in viable pregnancies and 31 IU/l in non-viable pregnancies (P < 0.0001). Early pregnancy Every woman is different and has her own hCG numbers after IVF. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. Day 11: The embryo is surrounded by fluid inside the amniotic sac. lower end of this range might indicate a problem with embryo implantation. All biochemical pregnancies were found at hCG levels < 100 mIU/mL. Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. An online IVF hCG calculator is based on the assumption that at least one day has passed. No correlation between age and HCG level was observed in viable pregnancies (P = NS). 1995 Jan;12(1):13-4. doi: 10.1007/BF02214122. Multiple pregnancies which resulted in an sab had a median hCG concentration of 196.54 IU/l which was also significantly lower compared to serum hCG concentrations in live multiple birth/ongoing pregnancies. Im 16weeks 1day today and everything looks great! HCG concentrations (IU/l) in viable and non-viable pregnancies, Treatment type and outcome of pregnancies, Aetiology of infertility and outcome of pregnancies. Dont be afraid to ask them what they think is going on and what your chances are of success given the information at hand. Can biochemical pregnancy be determined 5 days after frozen-thawed embryo transfer? Conclusion: Serum hCG concentration on day 12 following embryo transfer may be a useful prognostic tool in counseling patients regarding pregnancy outcome. Hoping it continues! The mean -hCG concentrations based on maternal age (23-33 years vs 34-45 years) were obtained (357.9 + 276.7 vs 269.5 244.4 mIU/mL), where the differences in both groups did not differ significantly statistically (p = 0.206). The same was true for the subgroup of male factor infertility. Have questions about your order or products? IVF is successful when you have a healthy, viable pregnancy after the embryo transfer. Im so worried so ago) and I know I shouldnt have but I took a pregnancy today and it was negativehas anyone got a little advice from my midwife to all the bleeders out ther Is it normal to experience breast tender _heaviness or painf **Sensitive** hCG 1259 @ 11 days post a 5 day embryo transfer, Pregnancy test 4 days after embryo transfer. All content and information on this website are for informational and educational purposes only. The measured HCG values were non-normally distributed. There are other medical reasons that could be behind an unusually high beta hCG. The above hCG levelsare only a guide. With that said,I recommend that you dont check a urine home pregnancy test. Our results suggest that the HCG concentrations are similar even when no ovarian stimulation is used. Human chorionic gonadotropin (hCG) is the first hormonal message from the placenta to the mother. That is why we recommend that you get an office blood test, which is a quantitative test that provides a numeric value for the hormone hCG. It is used to diagnose pregnancy and a result greater than 5 mIU/mL is generally considered positive. J Assist . The intra-assay variation was 2.7-5.1% and inter-assay variation 1.6-3.9% at the studied HCG levels. (, Homan, G., Brown, S., Moran, J., Homan, S. and Kerin, J. It had increased from a 99 from the day before. The real date may be slightly different. Try and relax enjoy being pregnant! My REs office does first beta 13dp5dt and then two days later but mine happened to fall on a weekend. Might be a slow starter. Our study did not include comparison with spontaneous pregnancies, but others have reported that early HCG in spontaneous pregnancies is higher than that in the IVF pregnancies (Tulchinsky et al., 1996; Ertzeid et al., 2000). One hundred eleven patients had positive serum quantitative hCG levels 14 days post-ET; 89/111, or 80.2%, had ongoing pregnancies. Beta HCG levels vary according to the gestational age. Sometimes, women will ask if their hCG level in doubling timeis normal. The previous studies on ART cycles relating early HCG determination with pregnancy outcome consisted of 77662 cycles and have been reviewed (Sugantha et al., 2000). They are typically about 100 mIU/ml 14 days after . Serum HCG has been found to be predictive of pregnancy outcome. My beta showed I was pregnant and then the 2nd blood work, my numbers had dropped. FET after miscarriage - looking for some hope and positivity. One study found that median hCG levels on Day 13 after a fresh embryo transfer were 329 for women with one baby and 544 for women carrying twins. How long after IVF will you conceive? However, the HCG values in non-viable pregnancies remained non-normally distributed even after logarithmic or exponential transformations. If your hCG is rising, but not doubling, it doesnt necessarily mean that something is wrong. Some or all of the eggs will be fertilized. The spontaneous miscarriage rate was, therefore, 19.8% (22/111). (, Ertzeid, G., Tanbo, T., Dale, P.O., Storeng, R., Morkid, L. and byholm, T. (, Frattarelli, J., Leondires, M., Miller, B. and Segars, J. This very question was addressed by a group from Finland (Poikkeus P. et al, Serum hCG 12 days after embryo transfer in predicting pregnancy outcome. In particular, patients with tubal factor infertility are at an increased risk of EP and should therefore receive special attention to avoid further impairment of fertility. Use of this site is subject to our terms of use and privacy policy. A home test can first detect hCG levels that indicate pregnancy about 12-14 days after conception. Create an account or log in to participate. With that said, levels in the lower end of this range might indicate a problem with embryo implantation. Progesterone levels rise much differently than hCG levels, with an average of 1-3mg/ml every couple days until they reach their peak for that trimester. Neither was there a difference between the medians of the 18 natural and the 54 substituted cycles (111 versus 123 IU/l; NS). Bethesda, MD 20894, Web Policies In patients that are having biochemical pregnancies, miscarriages or tubal pregnancies, the levels will not rise appropriately. At this point, if the embryo has implanted, you will also get a positive urine pregnancy test. In substituted frozen embryo transfer cycles, hormone replacement with estradiol valerate given orally (46 mg daily) was used until endometrial thickness reached 7 mm per two layers. MeSH terms Chorionic Gonadotropin / blood* Embryo Transfer* Fallopian Tube Diseases / complications Female Forecasting Humans What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. About 10 days after your transfer, your doctor will have you come in for a blood test to check your human chorionic gonadotropin (or hCG) levels. Another study found thatgender-related difference inHCG does existas early as three weeks after fertilization, but thatthe difference is not strong enough to be used to predict fetal sex"because of the small proportion of pregnant women with serum HCG concentrations that are high or low enough to allow a prediction with high probability". Initially, hCG levels are quite high. as low as 50 or as high as 1,000+ mIU/mL. This ultrasound is much more predictive of pregnancy outcomes than hCG levels. Today I am 8dp5dt and had my beta done. Shipping is not available outside of the United States. The .gov means its official. Hello I am 42 years old and this is my first ivf. I am definitely feeling much more at ease after hearing these comments thank you. 2022 Jan 17;26(1):62-67. doi: 10.5935/1518-0557.20210054. I am Sumer nervous as my digital is not reading pregnant so it means my HCG is lower Praying it doubles tomorrow, Need hope! Next appt is in two weeks for an US. 203 mIU/ml is a high result 12 days after embryo transfer, but not so high. Oh my gosh! Day 3: The blastocyst attaches deeper into the uterine lining, beginning implantation. 191: Tubal Ectopic Pregnancy, Obstetrics & Gynecology: February 2018 Volume 131 Issue 2 p e65-e77doi: 10.1097/AOG.0000000000002464. HCG level 15 days after embryo transfer AmyK227 3 months ago 8 Replies Yesterday at 15dp5dt I went for a blood test and my HCG is only 150. Had we chosen a cut-off level of 41 IU/l, the sensitivity would have risen to 97%, but the specificity would have decreased to 62%. Patients identified as having a biochemical pregnancy were found to have median hCG levels of 36.15 IU/l. So, in order to use the calculator, you need to take your own hCG levels and also keep track of exactly when the tests were taken. In some IVF cycles, fresh embryos are transferred, while in other cases, frozen embryos can also be transferred to the uterus. The aetiology of infertility played some role in our study. The normal hCG levels for twins is 30% to 50% higher than in single pregnancy- somewhere around 200 to 1750 mIU/ml. Helping mothers, protecting Mother Earth. Day 2: The blastocyst continues to hatch out of its shell and begins to attach itself to the uterus. I'm just too scared to be excited about the positive beta/pregnancy. Group Black's collective includes Essence, The Shade Room and Naturally Curly. An abdominal ectopic pregnancy following a frozen-thawed ART cycle: a case report and review of the literature. Our cut-off level for predicting a viable pregnancy (76 IU/l) was slightly higher than those reported for similar (80%) sensitivity: 42 mIU/ml (Qasim et al., 1996); 55 IU/l (Bjercke et al., 1999); and 50 IU/l (Sugantha et al., 2000). Early -hCG levels predict live birth after single embryo transfer. ;). At day 12 after embryo transfer, each patient had her HCG level assessed. But you should not have to worry about determining the stage of the embryos at transfer. Day 10: By the 10th to 12th day of development, the blastocyst is fully implanted. Please whitelist our site to get all the best deals and offers from our partners. Pregnancies were classified as viable (live fetus at > or =22 weeks gestation) or non-viable (biochemical pregnancy, miscarriage, ectopic pregnancy and molar pregnancy).

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